How are movements generated in spinal cord circuitry?
From where and how are movements generated? All our everyday activities are produced by cells in the spinal cord. But how do they accomplish the task? How many cells are involved and how do they produce the rhythm and coordinate the muscles? Our lab investigates how simple stereotypic movement such as walking, running and scratching emerge out of the biological networks of neurons primarily located in the spinal cord.
Our lab focus on the neuronal ensemble dynamics in order to tease apart the spinal circuitry involved in generation of simple movements, and the orchestration by the brain. We use the following experimental techniques:
- Intracellular recordings of a single neuron embedded in an active network (brain or spinal cord).
- Simultaneous multi-unit recording (~300 neurons) from spinal motor network activity.
- Advanced analysis techniques (done in mostly in Matlab).
We put emphasis on having a strong data-driven analysis including advanced analytical tools as well as mathematical modelling.